hearing loss pill Hough Ear Institute

Biotech Company Acquires Hearing Loss Drug Discovered by Hough Ear Institute Scientists

OKLAHOMA CITY (FEB 11, 2020) – Hough Ear Institute (HEI), a nonprofit based in Oklahoma City, is proud to announce that its pharmaceutical partner, Auditus LLC (Auditus), a wholly owned subsidiary of Otologic Pharmaceutics Inc. (OPI), has entered into an agreement with Oblato Inc. (Oblato). Oblato assumes exclusive rights to a drug known as NHPN-1010 to advance clinical research in the field of preserving and possibly restoring hearing.

Hearing loss is commonly caused when repeated or overpowering noise energy causes the ear to act like an engine in overdrive, which causes toxins to accumulate in the sensitive sensory cells and nerves of the inner ear. NHPN-1010 short-circuits this cascade of events and soaks up the harmful toxins. 

HEI and the Oklahoma Medical Research Foundation (OMRF) jointly discovered the NHPN-1010 technology and licensed it to OPI for commercial development in 2010. OPI led a successful Phase I clinical trial to demonstrate safety in 2015. HEI continued to conduct research with the drug and recently discovered that it has the ability to regenerate and reconnect damaged nerve endings on surviving hair cells, which was once thought to be irreversible. 

As part of the agreement between Auditus and Oblato, Oblato is expected to initiate a Phase II clinical trial to evaluate the potential of the drug to prevent and treat hearing loss. Follow-up studies may test efficacy for treating tinnitus and improving ability to understand speech in the presence of background noise.

Worldwide, 466 million people suffer from disabling hearing loss, one in seven individuals experience tinnitus and over 324,000 registered cochlear devices have been implanted. Here at home, 48 million Americans are affected by hearing loss, with 50 million suffering from tinnitus. Of those, about 58,000 people are right here in Oklahoma. 

At this time, no drug treatment or cure exists for noise induced hearing loss (NIHL) or tinnitus.

Dr. Richard Kopke, CEO of the Hough Ear Institute, said a team effort brought the technology to this stage.

“The research team at HEI, Dr. Robert Floyd and Manu Nair of the Oklahoma Medical Research Foundation (OMRF), as well as Dr. Richard Gammans, CEO of OPI have been collaboratively performing extensive preclinical and clinical research of this therapy, thanks to generous research grants from the Department of Defense (DOD), which we hope will bring relief to millions of people worldwide who suffer from NIHL and cochlear implant trauma,” Kopke said.

“Funds from many generous donors and investors from the Oklahoma City community and beyond made the impossible possible through innovation,” Kopke said. “OPI investors including Innovation to Enterprise (I2E), the Chickasaw Nation, OMRF, INTEGRIS Baptist Medical Center (IBMC), the Oklahoma Life Science Fund, REHCO, LLC, Presbyterian Health Foundation, together with significant grant funding from the Oklahoma Center for the Advancement of Science & Technology (OCAST) and funding from generous donors worldwide have all played a significant role in moving this research forward. Under the leadership of Stan Hupfeld and then Bruce Lawrence, IBMC’s generous collaborative support established the foundation that led to these breakthroughs. We want to extend a special thank you to other generous donors who made this possible.”

Those supporters include: 

  • Jasco Giving Hope Foundation 
  • The Tom L. Ward Family Foundation 
  • The Meinders Foundation 
  • Records-Johnston Family Foundation
  • Kimray 
  • Charles and Barbara Taylor 
  • Pumps of Oklahoma 
  • Express Employment Professionals 
  • Hough Ear Institute Board of Directors 
  • Generous monthly and annual donors worldwide 

About Hough Ear Institute
Hough Ear Institute (HEI) is a nonprofit 501(c)(3) organization committed to restoring hearing worldwide through research, teaching and humanitarian efforts. 

About Oblato, Inc.
Oblato, Inc., a wholly-owned subsidiary of the Korean biotech company GtreeBNT, is incorporated in Delaware and has its principal place of business in New Jersey. Since 2016, the company has been developing a new drug, OKN-007, to treat glioblastoma multiforme (GBM). Currently, clinical trials are ongoing to investigate the safety and efficacy of a combination therapy with both OKN-007 and temozolomide for patients with newly diagnosed GBM. The company has lately acquired worldwide exclusive rights of NHPN-1010 for the prevention and treatment of human hearing loss and its relevant diseases, balance disorders, tinnitus and noise induced traumatic brain injury.

Media Contact:

Chloe Cumbie

405-808-4837 (C)


11 Comments, RSS

  • Bob Colston

    says on:
    March 2, 2020 at 2:11 PM

    I would definitely volunteer for the study on tinnitus.
    Thank you

  • Dennis W Dant

    says on:
    March 3, 2020 at 8:23 AM

    Hello and thank you for your efforts. I am 60 years old and have Menieres disease. I had my left ear balance nerve destroyed because of vertigo issues and dizziness .I have alot of hearing loss and tinnitus, Is this something that could possibly help me in the future? Thank you!

  • Ralph Wampler

    says on:
    March 3, 2020 at 4:56 PM

    I would like to get on the trials for the pill to improve hearing. Thanks.

  • Warren Wright

    says on:
    March 4, 2020 at 11:28 AM

    I live two miles from the Hough office in OKC. I’m 69 and have partial hearing loss and tinnitus. I would like to volunteer for any studies regarding NHPN-1010 if that is a possibility.

    Warren Wright
    405 613-0154

  • Erica

    says on:
    March 5, 2020 at 7:32 AM

    How do i become part of this study

  • Jason Palos

    says on:
    March 5, 2020 at 8:04 AM

    I’m happy to participate in the trial if subjects with hearing loss and tinnitus are needed.

  • Jan

    says on:
    March 5, 2020 at 9:59 PM

    What is the estimated release for the medication, please? If you are seeking people to be trial volunteers, please consider my Father and me. We are responsible and compliant individuals. Thank you in advance for your consideration.

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  • prakash gc

    says on:
    March 12, 2020 at 8:52 AM

    im from india, im suffering with tinnitus from last one year i tried lots of treartment but it not effect on tinnitus or reduce it. im happy to hear that u r discovering treatment for cure, my request is bring it to market as soon as possible.

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