Publications

Development of a Temporary Threshold Shift Model of Chronic Noise-Induced Tinnitus with Evidence of Altered Auditory Signaling Pathway Inhibition

March 11, 2025

Response to OKN-007 and NAC in a Patient with Unilateral Hearing Loss and Chronic Tinnitus from Vestibular Schwannoma

Enhanced cryoprotective effect of sucrose on the physicochemical stability of colloidal systems: a case study with siRNA-loaded poly (lactic-co-glycolic acid) nanoparticles

October 28, 2022

Electrophysiological Assessment and Pharmacological Treatment of Blast-Induced Tinnitus

January 7, 2021

Gene therapy for hair cell regeneration: Review and new data

July 13, 2020

Cochlear hair cell regeneration: an emerging opportunity to cure noise-induced sensorineural hearing loss.

May 4, 2018

Regeneration of Cochlear Hair Cells and Hearing Recovery through Hes1 Modulation with siRNA Nanoparticles in Adult Guinea Pigs

May 2, 2018

HPN-07, a free radical spin trapping agent, protects against functional, cellular and electrophysiological changes in the cochlea induced by acute acoustic trauma

October 9, 2017

siRNA-loaded biodegradable nanocarriers for therapeutic MAPK1 silencing against cisplatin-induced ototoxicity

October 9, 2017

Antioxidants reduce neurodegeneration and accumulation of pathologic Tau proteins in the auditory system after blast exposure

May 16, 2017

Ameliorative effects of antioxidants on the accumulation of hippocampal pathologic Tau variants in a rat model of blast-induced traumatic brain injury.

December 16, 2015

Efficacy and safety of N-acetylcysteine in prevention of noise induced hearing loss: a randomized clinical trial

January 15, 2015

Antioxidants reduce phenotypic and functional changes in the inner ear and cochlear nucleus induced by intense noise

June 15, 2014

Effects of Antioxidant Treatment on Blast-Induced Brain Injury

November 5, 2013

Regeneration of mammalian cochlear and vestibular hair cells through Hes1/Hes5 modulation with siRNA

March 27, 2012

Magnetic targeted delivery of dexamethasone acetate across the round window membrane in guinea pigs

January 1, 2013

Selective degeneration of synapses in the dorsal cochlear nucleus of chinchilla following acoustic trauma and effects of antioxidant treatment.

January 1, 2012

Antioxidant treatment reduces blast-induced cochlear damage and hearing loss

March 1, 2012

Incorporation, Release and Effectiveness of Dexamethasone in Biodegradable Poly (lactic-co-glycolic acid) Nanoparticles for Inner Ear Drug Delivery. Journal of Nanotechnology in Engineering and Medicine. 2(1).

February 1, 2011

Reduced formation of oxidative stress biomarkers and migration of mononuclear phagocytes in the cochleae of chinchilla after antioxidant treatment in acute acoustic trauma International Journal of Otolaryngology, doi:10.1155/2011/612690 (2011)

January 1, 2011

Effects of Delayed and Extended Antioxidant Treatment on Acute Acoustic Trauma. Free Radic Res. 45(10):1162-72 (2011)

May 1, 2011

Dosing Study on the effectiveness of Salicylate/N-acetylcysteine for prevention of noise-induced hearing loss. Noise Health

July 1, 2010

Magnetic Assisted Transport of PLGA Nanoparticles Through a Human Round Window Membrane Model

August 2, 2010

Detecting incipient inner-ear damage from impulse noise with otoacoustic emissions

February 1, 2009

Pharmacological approaches to the prevention and treatment of cochlear injury due to noise.

July 2, 2009

American Academy of Audiology, Influence of Ultrahigh-Frequency Hearing Thresholds on Distortion-Product Otoacoustic Emission Levels at Conventional Frequencies

June 1, 2008

Effectiveness of 4-OHPBN alone and in combination with other antioxidant drugs in the treatment of acute acoustic trauma in chinchilla.

February 1, 2008

Magnetically-Targeted, Technetium 99m-Labeled Nanoparticles to the Inner Ear.

June 1, 2008

Nitrones as Therapeutics

November 15, 2008

Effectiveness of 4-hydroxy phenyl N-tert-butylnitrone (4-OHPBN) alone and in combination with other antioxidant drugs in the treatment of acute acoustic trauma in chinchilla

November 20, 2007

Risk factors for distortion product otoacoustic emissions in young men with normal hearing.

October 4, 2007

Distribution of PLGA nanoparticles in chinchilla cochleae.

October 1, 2007

Noise protection with N-acetyl-l-cysteine (NAC) using a variety of noise exposures, NAC doses, and routes of administration.

September 1, 2007

Pharmacological rescue of noise-induced hearing loss using N-acetylcysteine and acetyl-L-carnitine.

April 1, 2007

Magnetic Characterization of superparamagnetic nanoparticles pulled through model membranes.

January 4, 2007

Dispersion of super paramagnetic iron oxide nanoparticles in poly(d,l-lactide-co-glycolide) microparticles

January 1, 2007

NAC for noise: From the bench top to the clinic.

April 24, 2006

The permeability of SPION over an artificial three-layer membrane is enhanced by external magnetic field.

April 1, 2006

Magnetic nanoparticles: inner ear targeted molecule delivery and middle ear implant.

January 1, 2006

Efficacy of the antioxidant N-acetylcysteine (NAC) in protecting ears exposed to loud music.

April 17, 2006

Prevention of impulse noise-induced hearing loss with antioxidants.

March 1, 2005

Choline acetyltransferase: regulation and coupling with protein kinase and vesicular acetylcholine transporter on synaptic vesicles.

January 1, 2004

Mitochondrial dysfunction in hearing loss.

September 1, 2004

Transtympanic management of tinnitus.

April 2, 2003

Demonstration of functional coupling between grama-aminobutyric acid (GABA) synthesis and vesicular GABA transport into synaptic vesciles.

April 1, 2003

Vestibular testing abnormalities in individuals with motion sickness.

July 2, 2003

Effect of trans-bullar gentamicin treatment on guinea pig angular and linear vestibulo-ocular reflexes.

October 1, 2003